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M9640852.TXT
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1996-03-04
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Document 0852
DOCN M9640852
TI Satisfactory remission achieved by PUVA therapy in a case of crisis-type
adult T-cell leukaemia/lymphoma with generalized cutaneous leukaemic
cell infiltration.
DT 9604
AU Takemori N; Hirai K; Onodera R; Saito N; Yokota K; Kinouchi M; Takahashi
H; Iizuka H; Third Department of Internal Medicine, Asahikawa Medical
College,; Japan.
SO Br J Dermatol. 1995 Dec;133(6):955-60. Unique Identifier : AIDSLINE
MED/96150409
AB We used PUVA therapy in a patient with crisis-type adult T-cell
leukaemia/lymphoma and generalized cutaneous leukaemic cell
infiltration. PUVA proved very effective in reducing leukaemic cells and
in clearing the eruption. To understand the way in which PUVA produced a
reduction in the number of leukaemic cells, we examined peripheral blood
cells by light and electron microscopy. Light microscopy was of little
help, but electron microscopy revealed that PUVA induced apoptosis-like
changes in circulating leukaemic cells. This suggests that
apoptosis-like changes in leukaemic cells might be the reason for the
success of this treatment.
DE Apoptosis Case Report Human Leukemia-Lymphoma, T-Cell, Acute,
HTLV-I-Associated/*DRUG THERAPY/ PATHOLOGY Leukemic Infiltration/*DRUG
THERAPY Male Microscopy, Electron Middle Age *PUVA Therapy
Skin/*PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).